Bioinformatic Analysis of Alzheimer’s Disease Using Functional Protein Sequences

Bioinformatic Analysis of Alzheimer’s Disease Using Functional Protein Sequences

Over the past 25 years, it has become clear that the proteins forming the deposits are central to the disease process. Amyloid-ß and tau make up the plaques and tangles of Alzheimer’s disease(AD), where these normally soluble proteins assemble into amyloid-like filaments(Michel and Maria, 2006). Recently Ballatore et al. (2007) summarized the most recent advances in the mechanisms of tau-mediat...

Functional Protein Analysis of Hypertriglyceridemia: A Bioinformatic Approach

Hypertriglyceridemia is defined as an abnormal concentration of triglycerides in blood and is a commonly encountered lipid abnormality frequently associated with other lipid and metabolic derangements. Prolonged hypertriglyceridemia may produce neuropathological and abnormal metabolic changes particularly in peripheral sensory nerves. In the present study, we evaluated the role of several prote...

analysis of ruin probability for insurance companies using markov chain

در این پایان نامه نشان داده ایم که چگونه می توان مدل ریسک بیمه ای اسپیرر اندرسون را به کمک زنجیره های مارکوف تعریف کرد. سپس به کمک روش های آنالیز ماتریسی احتمال برشکستگی ، میزان مازاد در هنگام برشکستگی و میزان کسری بودجه در زمان وقوع برشکستگی را محاسبه کرده ایم. هدف ما در این پایان نامه بسیار محاسباتی و کاربردی تر از روش های است که در گذشته برای محاسبه این احتمال ارائه شده است. در ابتدا ما نشا...

Coevolution Analysis using Protein Sequences

Bioinformatic analysis of the protein/DNA interface

To investigate the principles driving recognition between proteins and DNA, we analyzed more than thousand crystal structures of protein/DNA complexes. We classified protein and DNA conformations by structural alphabets, protein blocks [de Brevern, Etchebest and Hazout (2000) (Bayesian probabilistic approach for predicting backbone structures in terms of protein blocks. Prots. Struct. Funct. Ge...